RESEARCH OF SCARRING PROCESS AFTER MODELLING OF NON-PENETRATING                             DEEP SCLERECTOMY IN THE EXPERIMENT 

Ivachev Evgeniy Aleksandrovich, Ophthalmologist, eye microsurgery unit № 3, Penza Regional Ophthalmological Hospital (32 Krasnaya street, Penza, Russia), eivachov1@yandex.ru
Fedorova Mariya Gennad'evna, Candidate of medical sciences, associate professor, sub-department of clinical morphology and forensic medicine with a course of oncology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), fedorovamerry@gmail.com
Mozerov Sergey Alekseevich, Doctor of medical sciences, professor, head of sub-department of morphology, Obninsk Institute for Nuclear Power Engineering, National Nuclear Research University “MEPhI” (1 Studgorodok street, Obninsk, Kaluga region, Russia), mozerov@list.ru
Savel'ev Mikhail Yur'evich, Head of eye surgery unit № 3, Penza Regional Ophthalmological Hospital (32 Krasnaya street, Penza, Russia), smy1970@gmail.com

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Background. The purpose of the work is to study healing and scarring of the surgery area during experimental modelling of non-penetrating deep sclerectomy in rabbits.
Material and methods. Rabbits of the 1st group were subject to non-penetrating deep sclerectomy with 20 coagulates on the sclera. Rabbits of the 2nd group underwent the identical operation, but without coagulates and with minimal damage. Then the researchers removed the samples and histologically researched the material of the surgery area in different periods after the operation.
Results. In the early postoperative period the micro- and macroscopic study showed that the rabbits of the 1st group had the expressed inflammatory reaction in the surgery area, but the rabbits of the 2nd group didn’t. Starting from the second week one could observe well-expressed scar tissue and vasculature with collateral anastomoses in the rabbits of the 1st group. The rabbits of the 2nd group featured the said results to a lesser extent.
Conclusions. The intraoperative diatermocoagulation provokes the expressed inflammatory reaction of the operating zone in the early postoperative period and the expressed scarring tissue and neovascularization later.

non-penetrating deep sclerectomy, glaucoma.

1. Baudouin C., Hamard P., Liang H. et al. Ophthalmology. 2004, vol. 111, no. 12, pp. 2186–2192.
2. Shmyreva V. F., Petrov S. Yu. Refraktsionnaya khirurgiya i oftal'mologiya [Refraction surgery and ophthalmology]. 2005, vol. 5, no. 1, pp. 5–13.
3. Alekseev B. N., Shmyreva V. F., Polutornov A. L. Vestnik oftal'mologii [Bulletin of ophthalmology]. 1986, no. 6, pp. 15–20.
4. Erichev V. P., Slepova O. S., Lovpache Dzh. N. Glaukoma [Glaucoma]. 2001, no. 1, pp. 11–17.
5. Lebedev O. I. Kliniko-eksperimental'noe obosnovanie prognozirovaniya i regulyatsii reparativnykh protsessov v khirurgii glaukomy: avtoref. dis. d-ra med. nauk [Clinicalexperimental substantiation of forecasting and regulating restorative processes in glaucoma surgeries: author’s abstract of dissertation to apply for the degree of the doctor of medical sciences]. Moscow, 1990, 41 p.
6. Chekmareva L. T., Yur'eva T. N., Shestakov A. O., Shchuko A. G. Byulleten' Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya Ros. akademii nauk [Bulletin of East-Siberian Scientific Center of the Siberian branch of the Russian academy of Sciences]. 2000, no. 4 (14), pp. 20–22.
7. Takhchidi Kh. P., Ivanov D. I., Kataeva Z. V., Bardasov D. B. Evro-Aziatskaya konferentsiya po oftal'mologii, 3-ya: Materialy [Third Euro-Asian ophthalmological conference: proceedings]. Ekaterinburg, 2003, part 3, pp. 91–93.
8. Bessmertnyy A. M. Sistema differentsirovannogo khirurgicheskogo lecheniya refrakternoy glaukomy: avtoref. dis. d-ra med. nauk [System of differential surgical treatment of refractory glaucoma: author’s abstract of dissertation to apply for the degree of the doctor of medical sciences]. Moscow, 2006, 43 p.
9. Vasilenkova L. V. Korrektsiya reparativnykh protsessov metodom lokal'noy tsitokinoterapii pri antiglaukomatoznykh operatsiyakh: avtoref. dis. kand. med. nauk [Correction of restorative processes by the method of local cytokine-therapy in anti-glaucoma surgeries: author’s abstract of dissertation to apply for th degree of the candidate of medical sciences]. Moscow, 2005, 24 p.
10. Sung V. C., Bhar I. S. Eye. 2001, vol. 15, pp. 45–51.